Patient Progress Report: June 9, 2026

Progress Outcome Report

Patient: 64-year-old male
‍Dates of Care: May 11, 2026 – June 5, 2026

‍Treating Providers: Dr. Brandon Crawford, DC, FIBFN-CND and Dr. Marcella Madera, MD.
Supporting Providers: Sandra Belisch, APRN, FNP-C; Stacy Plaske, RN; Dr. Sara Wiatrek, DC MS; Kristin Hughes, OTR; Dr. Roby Urbanovsky, DC; Dr. Andrew Stone, DC; and Dr. Jeri LaVigne, EdD, PhD.

‍Program: Functional Neurology Rehabilitation Intensive Program utilizing the Catalyst Regenerative Integration Method™ with adjunctive regenerative medicine support including MuseCell therapy.

Clinical Background

The patient presented with a progressive neurological syndrome characterized by Parkinsonism with concern for an underlying neurodegenerative process, including possible Lewy Body Dementia. Primary symptoms included bilateral resting tremor, bradykinesia, impaired balance, short-term memory deficits, anosmia, visual-perceptual disturbances, anxiety, slowed processing speed, and progressive functional decline.

Initial examination demonstrated significant basal ganglia dysfunction, impaired rapid alternating movements, impaired finger tapping, olfactory deficits, frontal release signs, gait and balance abnormalities, and cognitive concerns involving memory and executive function. The patient additionally demonstrated significant short-term memory impairment resulting in difficulty navigating familiar environments, slowed processing speed, impaired executive function, emotional dysregulation, and progressive decline in fine motor skills affecting daily activities and musical performance.

The patient subsequently completed a three-week intensive neurological rehabilitation program focused on targeted neuroplasticity, sensory-motor integration, functional neurology interventions, photobiomodulation, autonomic regulation, regenerative medicine, and advanced rehabilitative therapies utilizing the Catalyst Regenerative Integration Method™ and MuseCell regenerative procedure.

qEEG Findings

Baseline qEEG (April 21, 2026)

Initial qEEG demonstrated significant diffuse cortical slowing characterized by elevated delta and theta activity across multiple cortical regions. Findings were consistent with impaired network efficiency, dysregulated cortical communication, and dysfunction involving memory, emotional regulation, attention, sensory integration, and default mode processing.

Notable findings included:

• Elevated Delta Z-score of +5.1 within the Posterior Cingulate Cortex (BA23)
• Elevated Theta Z-score of +3.6 within the Superior Parietal Lobule (BA7)
• Elevated Eyes Open Delta Z-score of +5.0 within the Fusiform Gyrus (BA37)
• Elevated Eyes Open Theta Z-score of +4.7 within the Inferior Parietal Lobule (BA40)
• Elevated Eyes Open Alpha Z-score of +3.4 within the Middle Temporal Gyrus (BA39)

Network analysis demonstrated:

• Default Mode Network (DMN) hypoactivity of approximately 47%
• Emotion Regulation Cortex (ERC) hypoactivity of approximately 13%
• Reduced functional engagement of memory-related temporal lobe structures
• Elevated pathology indices associated with excessive slow-wave activity
• Findings consistent with cortical inefficiency, reduced arousal regulation, impaired memory processing, and neurocognitive dysfunction

Collectively, these findings were consistent with widespread functional dysregulation involving limbic, temporal, parietal, and memory-related neural systems.

Post-Treatment qEEG (June 5, 2026)

Follow-up qEEG continued to demonstrate residual abnormalities, which would be expected in an individual with an ongoing Parkinsonian and potentially neurodegenerative presentation. However, several objective markers demonstrated favorable changes suggestive of improved network engagement and functional organization.

Neuroplastic Network Response

Comparison of pre- and post-treatment qEEG network analyses demonstrated measurable changes within several large-scale functional brain networks.

Most notable findings included:

• Reduction in Default Mode Network hypoactivity from approximately 47% to 20%
• Reduction in Emotion Regulation Cortex hypoactivity from approximately 13% to 2.5%
• Increased activation and engagement within Memory Network structures involving medial temporal lobe and hippocampal circuitry
• Improved recruitment of networks associated with internal cognitive processing, memory formation, emotional regulation, and self-referential awareness
• Improved overall network organization despite persistence of underlying slow-wave abnormalities

These findings suggest improved functional engagement of neural systems involved in memory processing, emotional regulation, cognitive integration, and neuroplastic adaptation.

Memory Network Findings

Particularly notable was increased activation within the Memory Network, which is heavily dependent upon medial temporal lobe and hippocampal function.

Given the patient's significant baseline complaints of:

• Short-term memory loss
• Getting lost in familiar environments
• Difficulty maintaining cognitive clarity
• Potential Lewy Body pathology

the observed increase in memory network engagement is clinically meaningful and correlates favorably with observed functional improvements during treatment.

Default Mode Network Findings

The Default Mode Network demonstrated one of the most significant objective changes.

Baseline findings revealed substantial hypoactivity within this network, which has been associated with impaired cognitive flexibility, memory retrieval, internal processing, and executive function.

Following treatment:

• DMN hypoactivity improved by more than 50%
• Connectivity patterns became more organized
• Functional engagement of cortical hubs improved

These findings suggest improved baseline cortical readiness and improved integration of large-scale neural communication networks.

Emotion Regulation Network Findings

The Emotion Regulation Cortex demonstrated measurable improvement, with hypoactivity decreasing substantially during the treatment period.

This objective finding correlates with clinical observations including:

• Increased social engagement
• Improved mood
• Greater emotional positivity
• Increased participation in meaningful social interactions
• Reduced caregiver concern regarding progression

Interpretation

While significant slow-wave abnormalities remain present and are consistent with an ongoing Parkinsonian and/or neurodegenerative process, the post-treatment qEEG demonstrates evidence of improved functional organization, improved network engagement, enhanced memory-network recruitment, and improved emotional-regulatory processing.

Given the short duration of treatment and severity of presentation, these objective changes are clinically meaningful and suggest a favorable neuroplastic response to intervention.

Clinical Examination Outcomes

Motor Function

Initial Findings:

• Finger tapping significantly slowed with breakdown of rhythm
• Rapid alternating movements impaired bilaterally
• Bradykinetic movement pattern
• Fine motor impairment affecting daily activities
• Tremor prevented guitar playing
• Forward deviation on Fukuda stepping test
• Micrographia-like changes in handwriting
• Difficulty with fine motor tasks such as battery insertion

Post-Treatment Findings:

• Finger tapping markedly improved from baseline
• Diadochokinesia improved
• Movement speed increased
• Improved coordination and motor sequencing
• Persistent but reduced left-sided breakdown during sustained effort
• Tremor remained present but with improved overall motor performance
• Caregiver reported noticeable increase in movement speed
• Improved execution of motor tasks throughout treatment

Balance and Vestibular Function

Initial Findings:

• Dizziness and balance impairment
• Forward deviation on Fukuda stepping testing
• Family reported gait deterioration

Post-Treatment Findings:

• Significant improvement in balance reported during intensive program
• Improvement became most apparent during final treatment days
• Fukuda stepping test improved from anterior-left deviation to anterior deviation only
• Improved vestibular integration and hemispheric balance
• Improved postural control and spatial orientation

Olfactory Function

Initial Findings:

• Severe anosmia present for greater than ten years
• Right nostril demonstrated better identification than left
• Marked asymmetry in olfactory processing

Post-Treatment Findings:

• Bilateral improvement in odor detection
• Left nostril improved from inability to detect scent to detectable scent awareness
• Right nostril improved to identification of peppermint at approximately 5–6 inches
• Improved olfactory discrimination bilaterally
• Persistent left-sided deficit remained but demonstrated measurable improvement

This finding is particularly noteworthy given the close relationship between olfactory pathways, limbic circuitry, hippocampal networks, and neurodegenerative disorders including Parkinson's disease and Lewy Body Dementia.

Cognitive and Behavioral Findings

Initial Findings:

• Significant short-term memory impairment
• Difficulty navigating familiar environments
• Impaired executive function
• Slowed processing speed
• Increased emotionality and anxiety
• Reduced cognitive confidence
• Difficulty maintaining mental clarity

Post-Treatment Findings:

• Improved engagement and social interaction
• Improved mood and positive affect
• Increased happiness and social connectedness
• Improved orientation and conversational abilities
• Improved confidence and participation
• Reduced concern regarding progressive decline expressed by caregiver
• Increased ability to engage in meaningful and enjoyable activities