Quantitative EEG Interval Analysis: Comparison of Baseline and Post-Intervention Neurophysiological Findings

Quantitative EEG Interval Analysis: Comparison of Baseline and Post-Intervention Neurophysiological Findings

Patient: 69-year-old male with Parkinson's disease
‍Baseline Evaluation: June 15, 2026
‍Follow-up Evaluation: June 26, 2026

‍Treating Providers: Dr. Brandon Crawford, DC FIBFN-CND and Dr. Marcella Madera, MD. Supporting Providers: Sandra Belisch, APRN, FNP-C; Dr. Sara Wiatrek, DC MS; Kristin Hughes, OTR; Dr. Roby Urbanovsky, DC; Dr. Andrew Stone, DC; Dr. Jeri LaVigne, EdD, PhD; Stacy Plaske, RN.

‍Program: Functional Neurology Rehabilitation Intensive Program utilizing the Catalyst Regenerative Integration Method™ with adjunctive regenerative medicine support including an autologous plasma based VSEL and extracellular vesicle procedure.

Clinical Outcome Summary

Following two weeks of intensive neurological rehabilitation and one treatment consisting of VSELs and extracellular vesicles, both the patient and his spouse independently reported meaningful functional improvements compared with baseline.

• Improved speech volume and vocal projection
• Improved speech prosody with more natural inflection and expression
• Faster overall movement and improved ease of mobility
• Improved mood and emotional well-being
• Improved cognitive function, including greater mental clarity and processing efficiency
• Improved sleep quality

Objective qEEG Summary

Comparison of the baseline and follow-up quantitative EEG examinations demonstrated objective interval changes in cortical electrophysiology following treatment. Overall findings suggest improved cortical efficiency and network organization while persistent abnormalities consistent with Parkinson's disease remain present.

Major Objective Improvements

• Normalization of excessive temporal delta activity.
• Normalization of average alpha power and alpha peak frequency.
• Reduction in diffuse beta abnormalities.
• Improved organization of the Default Mode Network.
• Marked improvement in the Dorsal Attention Network.
• Improved frontal executive network organization.
• Reduction in diffuse cortical hypoarousal.
• Improved functional connectivity with less diffuse abnormal coherence.
• Source localization demonstrated a trend toward improved cortical organization with less diffuse dysfunction.

Persistent Findings

• Persistent excessive theta activity consistent with Parkinsonian physiology.
• Residual frontal-subcortical dysfunction.
• Persistent executive network abnormalities.
• Continued cortico-basal ganglia-thalamic network dysfunction.

Clinical Interpretation

Taken together, the electrophysiologic findings suggest measurable improvement in cortical network function over the ten-day treatment interval. While the underlying neurodegenerative process remains evident, objective improvements were observed in cortical organization, alpha physiology, large-scale functional networks, and connectivity. These objective findings were accompanied by clinically meaningful improvements reported independently by both the patient and his spouse.

Clinical Impression

Overall, the combined clinical and neurophysiologic findings suggest interval improvement in cortical network efficiency and functional brain organization following a multimodal intensive neurorehabilitation program that included neurological rehabilitation and one administration of VSELs with extracellular vesicles. Although the observed changes cannot establish causality or determine the contribution of any individual treatment component, the concordance between objective qEEG findings and reported functional improvements supports continued longitudinal monitoring. Future follow-up should include serial qEEG evaluations in conjunction with standardized neurological examinations, gait analysis, cognitive testing, and Parkinson's rating scales.